is the scarring process that represents the liver’s response to injury. In the same way as skin and other organs heal wounds through deposition of collagen and other matrix constituents so the liver repairs injury through the deposition of new collagen.
Liver fibrosis is the most common liver condition. It is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-β1, angiotensin II, and leptin.
In the last several years, global Liver Fibrosis Drug market is with CAGR of -11.75% from 2014 to 2018. In 2018, global revenue of Interferon is nearly 14300 USD; the actual sales is about 164.162 million units.
The classification of Liver Fibrosis Drug includes nucleoside, interferon and others, and the proportion of nucleoside type in 2018 is about 45.37%, and the proportion keeps stable trend from 2014 to 2025.
Liver fibrosis drug is widely used for Hepatitis, Liver Fibrosis and Other. The most proportion of Interferon is used for hepatitis, and the proportion in 2018 is 68.37%.
North America is the largest consumption place, with a consumption market share nearly 47.09% in 2018. Following North America, Europe is the second largest consumption place with the consumption market share of 25.14%.
Market competition is intense. Gilead, Biogen Idec, Merck KGaA, Bristol-Myers Squibb Company, Roche, Merck & Co., Inc and Tri-Prime are the leaders of the industry, and they hold key technologies and patents, with high-end customers; have been formed in the monopoly position in the industry.