Price Barriers Challenge SME Adoption Despite 22.6% Market Growth

Nonspecific universal nuclease, a genetically engineered enzyme derived from Serratia marcescens. It can degrade all forms of DNA and RNA, including single-stranded, double-stranded, linear, circular, native and denatured nucleic acids, and digest them into 5-monophosphate oligonucleotides of 3-8 bases in length, without base recognition specificity. In addition, nonspecific universal nuclease can maintain high stability and digestive activity under a wide range of conditions (6M urea, 0.1M guanidine hydrochloride, 0.4% Triton X100, 0.1% SDS, 1mM EDTA, 1mM PMSF), and is very suitable as the preferred enzyme preparation for various scientific research and vaccine, protein, and polysaccharide drug industries, used to remove nucleic acid residues in samples or products, and improve sample purity and product biological efficacy.

With the development of genomics, precision medicine and personalized medicine, the demand for efficient and accurate nucleases in scientific research and clinical fields continues to rise. As an enzyme with wide application in DNA/RNA processing, cutting and modification, non-specific universal nucleases have become a basic tool in various genomic research and medical diagnosis. With the popularization of gene editing technologies such as CRISPR technology and the progress of biotechnology and synthetic biology, the demand for non-specific nucleases will continue to grow.

The huge investment in genomics, precision medicine, cancer treatment and other life sciences in Europe and the United States, as well as the policy support of various institutions including the National Institutes of Health (NIH) and EU countries in gene editing and biotechnology have promoted the demand for non-specific nucleases. The strong demand for efficient nuclease tools in scientific research institutions has further promoted the development of the market.

Although the market demand for high-end scientific research tools in Europe and the United States is large, the price issue is still an important factor restricting the popularization of non-specific nucleases. Especially in some small and medium-sized biological companies or scientific research institutions, they will face legal and ethical supervision at the same time, which will form certain obstacles.

In general, Europe and the United States have strong scientific research infrastructure and technological innovation capabilities. Driven by the demand for genomics, precision medicine and biopharmaceutical industries, universities, research institutions and biotechnology companies in these regions have driven the growth of the nuclease market, and the application areas of the market continue to expand.

According to the new market research report “Global Nonspecific Universal Nuclease Market 2025 by Company, Regions, Type and Application, Forecast to 2031”, published by Global Info Research, the global Nonspecific Universal Nuclease market size is projected to reach USD 0.66 billion by 2030, at a CAGR of 22.6% during the forecast period.

Figure1. Global Nonspecific Universal Nuclease Market Size (US$ Million), 2019-2030

Figure2. Global Nonspecific Universal Nuclease Top 20 Players Ranking and Market Share (Ranking is based on the revenue of 2023, continually updated)

According to Global Info Research Top Players Research Center, the global key manufacturers of Nonspecific Universal Nuclease include Merck, Thermo Fisher Scientific Inc., New England Biolabs, Bio-Techne Corporation, GenScript, AMSBIO, Sino Biological, ACROBiosystems, Vazyme, Novoprotein, etc. In 2023, the global top 10 players had a share approximately 80.0% in terms of revenue.

Figure3. Nonspecific Universal Nuclease, Global Market Size, Split by Product Segment

In terms of product type, currently GMP is the largest segment, hold a share of 44.6%.

Figure4. Nonspecific Universal Nuclease, Global Market Size, Split by Application Segment

In terms of product application, currently Laboratory is the largest segment, hold a share of 54.5%.

Figure5. Nonspecific Universal Nuclease, Global Market Size, Split by Region

The content of the study subjects, includes a total of 15 chapters
Chapter 1, to describe Nonspecific Universal Nuclease product scope, market overview, market estimation caveats and base year.
Chapter 2, to profile the top manufacturers of Nonspecific Universal Nuclease, with price, sales, revenue and global market share of Nonspecific Universal Nuclease from 2020 to 2025.
Chapter 3, the Nonspecific Universal Nuclease competitive situation, sales quantity, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.
Chapter 4, the Nonspecific Universal Nuclease breakdown data are shown at the regional level, to show the sales quantity, consumption value and growth by regions, from 2020 to 2031.
Chapter 5 and 6, to segment the sales by Type and application, with sales market share and growth rate by type, application, from 2020 to 2031.
Chapter 7, 8, 9, 10 and 11, to break the sales data at the country level, with sales quantity, consumption value and market share for key countries in the world, from 2020 to 2025.and Nonspecific Universal Nuclease market forecast, by regions, type and application, with sales and revenue, from 2025 to 2031.
Chapter 12, market dynamics, drivers, restraints, trends and Porters Five Forces analysis.
Chapter 13, the key raw materials and key suppliers, and industry chain of Nonspecific Universal Nuclease.
Chapter 14 and 15, to describe Nonspecific Universal Nuclease sales channel, distributors, customers, research findings and conclusion.

For more information, please refer to "Global Nonspecific Universal Nuclease Market 2025 by Company, Regions, Type and Application, Forecast to 2031". This report analyzes the supply and demand situation, development status, and changes in the industry, focusing on the development status of the industry, how to face the development challenges of the industry, industry development suggestions, industry competitiveness, and industry investment analysis and trend forecasts. The report also summarizes the overall development dynamics of the industry, including the impact of the latest US tariffs on the global supply chain, the supply relationship analysis of the industrial chain, and provides reference suggestions and specific solutions for the industry in terms of products.